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DOI: 10.3390/ijerph19031244

In the next, extremely unfavorable elimination step (step 2), the conjugate base of the amine is kicked out from the tetrahedral intermediate: The reaction is driven to completion in a quick, irreversible deprotonation of the carboxylic acid by the newly formed RNH

In neuromyelitis optica, Aquaporumab, a monoclonal antibody targeting AQP4-IgG, has demonstrated therapeutic potential [419]

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